Published: Sun, March 04, 2018
Medical | By Vernon Walton

Researchers ID Five Distinct Adult-Onset Diabetes Subgroups

Researchers ID Five Distinct Adult-Onset Diabetes Subgroups

"Current diagnostics and classification of diabetes are insufficient and unable to predict future complications or choice of treatment", explains Professor Leif Groop, who initiated the study.

The researchers at Lund University Diabetes Centre in Sweden and the Institute for Molecular Medicine Finland examined 14,775 patients and their blood, conducting detailed analyses.

Millions more are thought to have prediabetes, or blood sugar levels that are above the normal range but not yet high enough to be classified as diabetic.

Severe autoimmune diabetes is largely the same as the classical type 1.

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Researchers ID Five Distinct Adult-Onset Diabetes Subgroups

There were patients whose cells also stopped producing insulin, but not due to their immune system; they were often young and in otherwise good shape.

But overall, the authors say that combining several different measurements to form a more specific diabetes diagnosis appears to be more useful than using just one-glucose levels-to simply diagnose type 1 or type 2. The study detailed that diabetes type 3 is the most resistant to insulin and those affected have a higher risk of getting a kidney disease than patients with variants 4 and 5.

The researchers observed that people in cluster 3 had a higher risk of kidney disease, while those in cluster 2 had higher risk of diabetic eye disease than people in other clusters.

While this group had the highest proportion of patients on the drug metformin, Groop said this was not the optimum treatment.


"Type 2 diabetes is usually caused by lifestyle factors and is preventable in most people".

The three severe forms could be treated more aggressively than the two milder ones, he said.

The mild diabetes related to age, which was most common (affecting between 39 and 47 percent of patients).

Researchers did not observe between-cluster differences for age- and sex-adjusted coronary event and stroke risk, and no genetic variant was associated with all the clusters.


The categories were discovered by considering six different metrics, including a measure of blood glucose control, age at diagnosis, BMI, the presence of certain antibodies linked to autoimmune diabetes, and a measure of insulin sensitivity.

Dr Salem said: "There is still a massively unknown quantity - it may well be that worldwide there are 500 subgroups depending on genetic and local environment effects".

FRIDAY, March 2, 2018 (HealthDay News) - Reclassification of diabetes into subgroups shows differing courses of disease progression and risk of diabetic complications, according to a study published online March 1 in The Lancet Diabetes & Endocrinology. It is also not clear if the different classifications have different causes. But researchers in Finland and Sweden say that there is a more complex picture, and that the results of their study will usher in a new period of personalized medications, the BBC reports.

"There are simple steps we can all take to reduce our chances of developing type 2 diabetes or reducing the seriousness of the condition, for example, by reducing our alcohol intake, stopping smoking, getting regular exercise and eating a healthy, balanced diet".


However, the percentage of people living with the condition in Dorset is slightly lower than the national average of 6.6%.

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